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KMID : 0613820090190050644
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Journal of Life Science
2009 Volume.19 No. 5 p.644 ~ p.651
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The Effect of Exercise Training (EXE) on Myocardium Glucose Metabolic Phenotypic Proteins and HSP-60 Protein Expression after Ischemia/Reperfusion Injury in STZ-induced Rats
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Bae Hee-Suk
Eum Hyun-Sub
Kang Eun-Bum
Yang Chum-Yeol
Lee Yong-Ro
Lee Chang-Guk
Cheon U-Ho
Jeon Hye-Ja
Cho In-Ho
Cho Joon-Yong
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Abstract
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The objective of this study was to identify EXE (1 hr a day at 21 m/min for 5 day/wk, at 0 % grade for 6 wk) on myocardium glucose metabolic phenotypic proteins (AMPK-PGC-1α-GLUT-4) and HSP-60 protein expression after ischemia/reperfusion injury (IRI) in STZ-induced rats. EXE was performed using STZ-induced diabetic rats on a rodent treadmill (28 m/min, 1 hr/day, 5 day/wk for 6 wk). The results of this study suggest that i) serum insulin level was not changed among groups (p＞0.05). ii) the LVDP level increased significantly in the STZ-EXE-IRI group compared to the STZ-IRI group at 60 min (p＜0.01), 70 min (p＜0.05) and 80 min (p＜0.05) after reperfusion, respectively, and iii) AMPK phosphorylation (p＜0.01), PGC-1α protein (p＜0.001), GLUT-4 protein (p＜0.001) and HSP-60 protein expressions (p＜0.05) increased significantly in the STZ-EXE-IRI group compared to the STZ-IRI group. In conclusion, the findings of the present study reveal that EXE may provide therapeutic value to insulin dependent diabetic patients with peripheral insulin resistance and myocardium injury by improving glucose metabolic proteins (AMPK-PGC-1α-GLUT-4) and heat shock protein-60 (HSP-60), along with increasing LVDP levels and decreasing glucose levels. Therefore, EXE protects the STZ-induced diabetic myocardium injury against ischemia/ reperfusion injury.
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KEYWORD
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Exercise training, ischemia/reperfusion injury, AMPK, PGC-1α, GLUT-4, HSP-60
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